Name Xiao-Qiang Yu Ph.D.
Dr. Yu investigates pattern recognition receptors (PRRs) involved in the innate immune system using a model insect. Insects have developed an effective and sophisticated immune system similar to the innate immune system of vertebrates. In the innate immune system, initial recognition of pathogens is mediated by PRRs that recognize structural molecular patterns present in molecules found in many microorganisms but not in host cells. Recognition of pathogens by PRRs is linked to immune responses such as phagocytosis, hemocyte nodule formation, encapsulation and melanization, activation of prophenoloxidase, and synthesis of antimicrobial peptides. Dr. Yu’s laboratory focuses on calcium-dependent (C-type) lectins as PRRs to initiate recognition process and mediate protein-protein interactions to localize prophenoloxidase activation on pathogen surface, and to trigger signal transduction pathways to activate antimicrobial genes.
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Kansas State University, Ph.D., Biochemistry
Zhongshan University (P. R. China), M.S., Chemistry
Zhongshan University (P. R. China), B.S., Chemistry
School of Biological Sciences
Pattern recognition receptors, innate immunity, signal transduction pathways