Name Jeffrey Price Ph.D.
Our lab is investigating circadian rhythms, which have periods of approximately 24 hours. For example, human sleep/wake behavior is a circadian rhythm. While responsive to environmental cycles, circadian rhythms are known to be generated within the organism because they persist under constant environmental conditions. Genetic approaches, which require the isolation and analysis of mutations affecting circadian rhythms, are revealing the cellular and molecular mechanisms of these “biological clocks.” Molecular analysis of clock genes affected in mutant fruit flies (Drosophila) has identified circadian transcription factors, photoreceptors and a protein kinase, which is the principal focus of our work. Using a combination of genetic, biochemical and immunocytochemical approaches, our lab is investigating how all of these components interact with the protein kinase to produce a functional clock. We also are investigating the role of this protein kinase in vertebrate clocks, which have a mechanism similar to the Drosophila one.
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College of William and Mary, B.S., Biology
Johns Hopkins University, Ph.D., Biology
Institute of Molecular Biology, Postdoc, Molecular Biology
Rockefeller University, Postdoc, Genetics
School of Biological Sciences
Drosophila genetics and circadian rhythms