Name Leonard Dobens Ph.D.
Dr. Dobens uses Drosophila to study intercellular signaling pathways that control cell proliferation, migration and differentiation during organ formation. Our focus is the regulation and function of the bunched gene, a fly transcription factor gene homologous to human tumor suppressor gene TSC-22 and mouse Glucocorticoid Induced Leucine Zipper (GILZ), which have diverse roles in vertebrate adipogenesis, erythrogenesis and lymphogenesis. In the fly, bunched regulates cell proliferation and migration and our long-term goal is to understand the conserved molecular mechanism by which bunched family members mediate cell signaling to direct tissue patterning. In a separate project, he studies how tissue-specific steroid hormone receptor responses regulate cell migration and DNA replication.
310 Spencer Chemistry
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Boston College, B.S., Biology
Dartmouth College, Ph.D., Molecular Genetics
School of Biological Sciences
Molecular and Biochemical Biology