Name Celestin Youan Pharm.D., Ph.D.
Dr. Youan's laboratory research interest is focused on the theoretical and experimental development and evaluation of bioactive agents loaded nanomedicine plateforms intended for spatial and temporal controlled release of drug for optimal delivery and targeting to various tissues such as brain, pulmonary, topical routes in the search of better strategy to treat or prevent diseases of high priority in public health.
For example, in the first area of novel topical drug delivery system, the work in progress (funded by NIH/NIAID) relates to microbicide loaded biocompatible nanomedicine intended for HIV/AIDS prevention. The second major research area of interest (funded by NIH/NIGMS) is the noninvasive delivery of bioactive macromolecules such as low molecular weight heparin based on the bioengineering of biocompatible microparticles with desirable aerodynamic/general features for controlled release into the alveolar region of the lung. Poor aerosol formulations and delivery systems are the two limitations to improving drug bioavailability through the pulmonary route. Improved particle engineering and various other approaches are being investigated to improve pulmonary bioavailability of bioactive macromolecules. Finally, novel delivery systems and emerging pharmaceutical technologies (e.g. nano/micro-engineering) are also investigated for controlled drug delivery into the brain with potential application to pharmacoresistant epilepsy patients (funded by New Therapy Grant of Epilepsy Research Foundation of America).
2464 Charlotte, Kansas City, MO 64108
Personal Web Page