Name Ashim Mitra Ph.D.
Vice Provost, Interdisciplinary Research, UMKC; Curators' Professor
Dr. Mitra’s research group has pioneered the use of a novel microdialysis technique to study ocular pharmacology of antiviral, antitumor and other anti-infective agents, has developed new techniques to implant multiple probes into both anterior and posterior chambers of the eye simultaneously. The work on peptide and protein delivery across pulmonary routes has taken him from animal models to cultured human lung epithelial cells. Using this cell line (Calu-3), his research team is investigating the role the apical membrane plays as compared to the basal membrane in controlling the transport of macromolecules. They have found the presence of a p-glycoprotein efflux system at the basal surface of these cells, which causes efflux of the peptide and peptidomimetics such as HIV-protease inhibitors out of the cytoplasm across the apical membrane. Currently, the focus is on the use of cell membrane natural transporters to deliver drugs to intracellular targets.
KPB-108C / M1-301
Office - Pharmacy
Office - Medicine
Personal Web Page
Jadavpur University, Calcutta, India, BS, Pharmacy
Jadavpur University, Calcutta, India, MS, Pharmacokinetics
University of Kansas, Lawrence, KS, MS, Pharmaceutical Chemistry
University of Kansas, Lawrence, KS, Ph.D., Pharmaceutical Chemistry
School of Medicine and School of Pharmacy