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Name Jerry Dias Ph.D.
Title
Curators Professor of Chemistry and Medicine
Research Description
The chemistry and molecular architecture of bile (cholic) acids, tetracyclic triterpenoids, and benzenoids are being investigated. Our research has resulted in the first transformation of cholic acid to derivatives of 17,19-dinorquassinoids, delineated the mechanism of electron impact induced fragmentation of the methyl ester triacetate of cholic acid through extensive deuterium labeling, identified a conversion of isocholesterol to a B-ring aromatic tetracyclic triterpenoid derivative by ejection of the C19-methyl, led to the discovery a diagnostic 13 C NMR y-oxygen shielding effect in cholic acid, and led to the synthesis and characterization of one of the largest open macrocycles ever subjected to X-ray crystallography.
Email diasj@umkc.edu
Office
Spencer Chemistry, C106
Personal Web Page
http://iml.umkc.edu/chem/faculty/dias.html
CV
Degrees
Arizona State University, Ph.D.
Stanford University, Postdoctoral Fellow
Schools
College of Arts & Sciences
Research Area
Organic synthesis and properties of bile acids and polycyclic aromatic hydrocarbons
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